› 1xau

X-ray diffraction
1.8Å resolution

STRUCTURE OF THE BTLA ECTODOMAIN

Released:
DOI: 10.2210/pdb1xau/pdb
PDB entry 1xau coloured by chain, front view.
PDB entry 1xau coloured by chain, side view.
PDB entry 1xau coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural determinants of herpesvirus entry mediator recognition by murine B and T lymphocyte attenuator.
Nelson CA, Fremont MD, Sedy JR, Norris PS, Ware CF, Murphy KM, Fremont DH
J Immunol 180 940-7 (2008)
PMID: 18178834

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182027 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B- and T-lymphocyte attenuator Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 14.15 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7TSA3 (Residues: 30-150; Coverage: 44%)
Gene name: Btla
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand CD 2 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 36.67Å b: 37.542Å c: 90.151Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 0.269
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation.
Cai et al. (2009)
10 more

4 mentions without citation

Towards fully automated structure-based function prediction in structural genomics: a case study.
Watson et al. (2007)
3 more