› 1xcr

X-ray diffraction
1.7Å resolution

Crystal Structure of Longer Splice Variant of PTD012 from Homo sapiens reveals a novel Zinc-containing fold

Released:
DOI: 10.2210/pdb1xcr/pdb
PDB entry 1xcr coloured by chain, front view.
PDB entry 1xcr coloured by chain, side view.
PDB entry 1xcr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold.
Manjasetty BA, Büssow K, Fieber-Erdmann M, Roske Y, Gobom J, Scheich C, Götz F, Niesen FH, Heinemann U
Protein Sci 15 914-20 (2006)
PMID: 16522806

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190500 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ester hydrolase C11orf54 Chains: A, B
Molecule details ›
Chains: A, B
Length: 316 amino acids
Theoretical weight: 35.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H0W9 (Residues: 2-315; Coverage: 100%)
Gene names: C11orf54, LP4947, PTD012
Sequence domains: Domain of Unknown Function (DUF1907)

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand ACY 2 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P21
Unit cell:
a: 44.572Å b: 52.888Å c: 124.485Å
α: 90° β: 88.89° γ: 90°
R-values:
R R work R free
0.19 0.19 0.222
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Supramolecular enzyme-mimicking catalysts self-assembled from peptides.
Liu et al. (2023)
5 other articles

3 mentions without citation

Structural genomics of human proteins--target selection and generation of a public catalogue of expression clones.
Büssow et al. (2005)
2 more