› 1xhn

X-ray diffraction
1.95Å resolution

The crystal structure of Cellular Repressor of E1A-stimulated Genes (CREG)

Released:
DOI: 10.2210/pdb1xhn/pdb
PDB entry 1xhn coloured by chain, front view.
PDB entry 1xhn coloured by chain, side view.
PDB entry 1xhn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation.
Sacher M, Di Bacco A, Lunin VV, Ye Z, Wagner J, Gill G, Cygler M
Proc Natl Acad Sci U S A 102 18326-31 (2005)
PMID: 16344469

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131087 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein CREG1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 184 amino acids
Theoretical weight: 20.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75629 (Residues: 49-220; Coverage: 91%)
Gene names: CREG, CREG1, UNQ727/PRO1409
Sequence domains: Pyridoxamine 5'-phosphate oxidase
Structure domains: Electron Transport, Fmn-binding Protein; Chain A

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 20 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P21212
Unit cell:
a: 106.13Å b: 121.26Å c: 55.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.162 0.213
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Structure and Biological Function of CREG.
Ghobrial et al. (2018)
27 other articles

3 mentions without citation

The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation.
Sacher et al. (2005)
2 more