› 1xjl

X-ray diffraction
2.59Å resolution

Structure of human annexin A2 in the presence of calcium ions

Released:
DOI: 10.2210/pdb1xjl/pdb
PDB entry 1xjl coloured by chain, front view.
PDB entry 1xjl coloured by chain, side view.
PDB entry 1xjl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Annexin A2: Does it induce membrane aggregation by a new multimeric state of the protein?
Rosengarth A, Luecke H
Annexins 1 129-136 (2004)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 319 amino acids
Theoretical weight: 36.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07355 (Residues: 21-339; Coverage: 94%)
Gene names: ANX2, ANX2L4, ANXA2, CAL1H, LPC2D
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand CA 14 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 61.781Å b: 98.105Å c: 176.273Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.264
Expression system: Escherichia coli

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Citations

5 mentions without citation

Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
Shao et al. (2006)
4 more