› 1xki

X-ray diffraction
1.8Å resolution

Crystal structure of human tear lipocalin/von Ebners gland protein

Released:
DOI: 10.2210/pdb1xki/pdb
PDB entry 1xki coloured by chain, front view.
PDB entry 1xki coloured by chain, side view.
PDB entry 1xki coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands.
Breustedt DA, Korndörfer IP, Redl B, Skerra A
J Biol Chem 280 484-93 (2005)
PMID: 15489503

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151894 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lipocalin-1 Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31025 (Residues: 23-176; Coverage: 98%)
Gene names: LCN1, VEGP
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 76.397Å b: 61.415Å c: 50.798Å
α: 90° β: 129.71° γ: 90°
R-values:
R R work R free
0.193 0.189 0.254
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Siderophore-based iron acquisition and pathogen control.
Miethke et al. (2007)
5 more

24 mentions without citation

Tear lipocalin: structure and function.
Dartt DA. (2011)
23 more