› 1xmw

Solution NMR

CD3 EPSILON AND DELTA ECTODOMAIN FRAGMENT COMPLEX IN SINGLE-CHAIN CONSTRUCT

Released:
DOI: 10.2210/pdb1xmw/pdb
PDB entry 1xmw coloured by chain, ensemble of 15 models, front view.
PDB entry 1xmw coloured by chain, ensemble of 15 models, side view.
PDB entry 1xmw coloured by chain, ensemble of 15 models, top view.
Source organisms:
Primary publication:
Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.
Sun ZY, Kim ST, Kim IC, Fahmy A, Reinherz EL, Wagner G
Proc Natl Acad Sci U S A 101 16867-72 (2004)
PMID: 15557001

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.96 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P22646 (Residues: 22-100; Coverage: 47%)
  • Canonical: P18438 (Residues: 17-21, 22-88; Coverage: 46%)
Gene names: CD3D, Cd3e
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Mechanisms for T cell receptor triggering.
van der Merwe et al. (2011)
19 more

11 mentions without citation

Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.
Wucherpfennig et al. (2010)
10 more