› 1xo5

X-ray diffraction
1.99Å resolution

Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein

Released:
DOI: 10.2210/pdb1xo5/pdb
PDB entry 1xo5 coloured by chain, front view.
PDB entry 1xo5 coloured by chain, side view.
PDB entry 1xo5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins.
Gentry HR, Singer AU, Betts L, Yang C, Ferrara JD, Sondek J, Parise LV
J Biol Chem 280 8407-15 (2005)
PMID: 15574431

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189279 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium and integrin-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 183 amino acids
Theoretical weight: 20.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99828 (Residues: 9-191; Coverage: 96%)
Gene names: CIB, CIB1, KIP, PRKDCIP
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 56.663Å b: 51.009Å c: 77.214Å
α: 90° β: 103.12° γ: 90°
R-values:
R R work R free
0.214 0.212 0.257
Expression system: Escherichia coli BL21(DE3)

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Citations

13 review citations

Inositol trisphosphate receptor Ca2+ release channels.
Foskett et al. (2007)
12 more

15 mentions without citation

Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP.
Lee et al. (2019)
14 more