› 1xr8

X-ray diffraction
2.3Å resolution

Crystal Structures of HLA-B*1501 in Complex with Peptides from Human UbcH6 and Epstein-Barr Virus EBNA-3

Released:
DOI: 10.2210/pdb1xr8/pdb
PDB entry 1xr8 coloured by chain, front view.
PDB entry 1xr8 coloured by chain, side view.
PDB entry 1xr8 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype.
Røder G, Blicher T, Justesen S, Johannesen B, Kristensen O, Kastrup J, Buus S, Gajhede M
Acta Crystallogr D Biol Crystallogr 62 1300-10 (2006)
PMID: 17057332

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135152 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01889 (Residues: 25-300; Coverage: 82%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Epstein-Barr nuclear antigen 3 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.03 KDa
Source organism: Human herpesvirus 4 strain B95-8
Expression system: Not provided
UniProt:
  • Canonical: P12977 (Residues: 406-414; Coverage: 1%)
Gene names: BLRF3-BERF1, EBNA3

Ligands and Environments

3 bound ligands:
Ligand PG4 1 x PG4
Ligand URE 1 x URE
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-5
Spacegroup: P212121
Unit cell:
a: 50.582Å b: 81.891Å c: 110.408Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.169 0.245
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

1 review citation

HLA-associated antiepileptic drug-induced cutaneous adverse reactions.
Mullan et al. (2019)
11 other articles

23 mentions without citation

Identification of drug-specific public TCR driving severe cutaneous adverse reactions.
Pan et al. (2019)
22 more