› 1xrw

Solution NMR

Solution Structure of a Platinum-Acridine Modified Octamer

Released:
DOI: 10.2210/pdb1xrw/pdb
PDB entry 1xrw coloured by chain, front view.
PDB entry 1xrw coloured by chain, side view.
PDB entry 1xrw coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Solution structural study of a DNA duplex containing the guanine-N7 adduct formed by a cytotoxic platinum-acridine hybrid agent.
Baruah H, Wright MW, Bierbach U
Biochemistry 44 6059-70 (2005)
PMID: 15835895

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114823 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*CP*TP*CP*GP*TP*CP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 8 nucleotides
Theoretical weight: 2.34 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*GP*GP*AP*CP*GP*AP*GP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 8 nucleotides
Theoretical weight: 2.52 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 2PT 1 x 2PT
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, molecular dynamics, matrix relaxation
Expression system: Not provided

Quick links

Citations

3 review citations

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.
Johnstone et al. (2016)
2 more

7 mentions without citation

Transition Metal Intercalators as Anticancer Agents-Recent Advances.
Deo et al. (2016)
6 more