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› 1xwa

X-ray diffraction
2.2Å resolution

Drospohila thioredoxin, oxidized, P41212

Released:
DOI: 10.2210/pdb1xwa/pdb
Model geometry
Fit model/data
PDB entry 1xwa coloured by chain, front view.
PDB entry 1xwa coloured by chain, side view.
PDB entry 1xwa coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster.
Wahl MC, Irmler A, Hecker B, Schirmer RH, Becker K
J Mol Biol 345 1119-30 (2005)
PMID: 15644209

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-194195 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 111 amino acids
Theoretical weight: 12.1 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9V429 (Residues: 1-106; Coverage: 100%)
Gene names: CG31884, Trx2
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand CD 3 x CD
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P41212
Unit cell:
a: 92.544Å b: 92.544Å c: 97.624Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.226 0.288
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Reactivity of thioredoxin as a protein thiol-disulfide oxidoreductase.
Cheng et al. (2011)
2 more

7 mentions without citation

Unifying mechanical and thermodynamic descriptions across the thioredoxin protein family.
Mottonen et al. (2009)
6 more