› 1xy2

X-ray diffraction
1.2Å resolution

CRYSTAL STRUCTURE ANALYSIS OF DEAMINO-OXYTOCIN. CONFORMATIONAL FLEXIBILITY AND RECEPTOR BINDING

Released:
DOI: 10.2210/pdb1xy2/pdb
PDB entry 1xy2 coloured by chain, front view.
PDB entry 1xy2 coloured by chain, side view.
PDB entry 1xy2 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ
Science 232 633-6 (1986)
PMID: 3008332

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxytocin Chain: A
Molecule details ›
Chain: A
Length: 10 amino acids
Theoretical weight: 977 Da
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P01175 (Residues: 21-28; Coverage: 8%)
Gene name: OXT
Sequence domains: Neurohypophysial hormones, N-terminal Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 27.08Å b: 9.06Å c: 22.98Å
α: 90° β: 102.06° γ: 90°
Expression system: Not provided

Quick links

Citations

15 review citations

Designing peptide receptor agonists and antagonists.
Hruby VJ. (2002)
14 more

10 mentions without citation

Chemistry and biology of multicomponent reactions.
Dömling et al. (2012)
9 more