› 1xzy

Solution NMR

Solution structure of the P30-trans form of Alpha Hemoglobin Stabilizing Protein (AHSP)

Released:
DOI: 10.2210/pdb1xzy/pdb
PDB entry 1xzy coloured by chain, ensemble of 20 models, front view.
PDB entry 1xzy coloured by chain, ensemble of 20 models, side view.
PDB entry 1xzy coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.
Feng L, Gell DA, Zhou S, Gu L, Kong Y, Li J, Hu M, Yan N, Lee C, Rich AM, Armstrong RS, Lay PA, Gow AJ, Weiss MJ, Mackay JP, Shi Y
Cell 119 629-40 (2004)
PMID: 15550245

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192741 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-hemoglobin-stabilizing protein Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9NZD4 (Residues: 1-90; Coverage: 88%)
Gene names: AHSP, EDRF, ERAF
Sequence domains: Alpha-haemoglobin stabilising protein
Structure domains: AHSP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

21 review citations

Oxidative stress in the regulation of normal and neoplastic hematopoiesis.
Ghaffari S. (2008)
20 more

2 mentions without citation

Alpha-hemoglobin stabilizing protein (AHSP), a kinetic scheme of the action of a human mutant, AHSPV56G.
Brillet et al. (2010)
1 more