› 1y13

X-ray diffraction
2.2Å resolution

Structural Analysis of Plasmodium falciparum 6-pyruvoyl tetrahydropterin synthase (PTPS)

Released:
DOI: 10.2210/pdb1y13/pdb
PDB entry 1y13 coloured by chain, front view.
PDB entry 1y13 coloured by chain, side view.
PDB entry 1y13 coloured by chain, top view.
Source organism: Plasmodium falciparum
Entry authors: Bosch J, Hol WGJ, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)

Function and Biology Details

Reaction catalysed: 
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo hexamer
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111623 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6-pyruvoyltetrahydropterin synthase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 181 amino acids
Theoretical weight: 21.17 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: C6KTB6 (Residues: 1-173; Coverage: 100%)
Gene name: PF3D7_0628000
Sequence domains: 6-pyruvoyl tetrahydropterin synthase
Structure domains: 6-pyruvoyl tetrahydropterin synthase/QueD

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand BIO 3 x BIO
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P43212
Unit cell:
a: 103.319Å b: 103.319Å c: 131.111Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.235
Expression system: Escherichia coli

Quick links