› 1y29

Solution NMR

Three dimensional solution structure of huwentoxin-x by 2D 1H-NMR

Released:
DOI: 10.2210/pdb1y29/pdb
PDB entry 1y29 coloured by chain, ensemble of 20 models, front view.
PDB entry 1y29 coloured by chain, ensemble of 20 models, side view.
PDB entry 1y29 coloured by chain, ensemble of 20 models, top view.
Source organism: Cyriopagopus schmidti
Primary publication:
Function and solution structure of Huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena.
Liu Z, Dai J, Dai L, Deng M, Hu Z, Hu W, Liang S
J Biol Chem 281 8628-35 (2006)
PMID: 16439354

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159396 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Omega-theraphotoxin-Hs1a Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 2.94 KDa
Source organism: Cyriopagopus schmidti
Expression system: Not provided
UniProt:
  • Canonical: P68424 (Residues: 41-68; Coverage: 58%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression system: Not provided

Quick links

Citations

5 review citations

Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs.
Estrada et al. (2007)
4 more

2 mentions without citation

Venoms of Heteropteran Insects: A Treasure Trove of Diverse Pharmacological Toolkits.
Walker et al. (2016)
1 more