› 1y6e

X-ray diffraction
3Å resolution

Orthorhombic glutathione S-transferase of Schistosoma japonicum

Released:
DOI: 10.2210/pdb1y6e/pdb
PDB entry 1y6e coloured by chain, front view.
PDB entry 1y6e coloured by chain, side view.
PDB entry 1y6e coloured by chain, top view.
Source organism: Schistosoma japonicum
Primary publication:
X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site.
Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M
Acta Crystallogr Sect F Struct Biol Cryst Commun 61 263-5 (2005)
PMID: 16511012

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase class-mu 26 kDa isozyme Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 26.07 KDa
Source organism: Schistosoma japonicum
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08515 (Residues: 2-218; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 161.22Å b: 50.75Å c: 57.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.211 0.279
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

The redox biology of schistosome parasites and applications for drug development.
Huang et al. (2012)
6 other articles

9 mentions without citation

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei.
Xiang et al. (2015)
8 more