› 1y8m

Solution NMR

Solution Structure of Yeast Mitochondria Fission Protein Fis1

Released:
DOI: 10.2210/pdb1y8m/pdb
PDB entry 1y8m coloured by chain, ensemble of 20 models, front view.
PDB entry 1y8m coloured by chain, ensemble of 20 models, side view.
PDB entry 1y8m coloured by chain, ensemble of 20 models, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.
Suzuki M, Neutzner A, Tjandra N, Youle RJ
J Biol Chem 280 21444-52 (2005)
PMID: 15809300

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154133 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial fission 1 protein Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.73 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P40515 (Residues: 1-138; Coverage: 89%)
Gene names: FIS1, MDV2, YIL065C
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, SIMULATED ANNEALING, MOLECULAR DYNAMICS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

18 review citations

Mitochondrial fusion and fission in mammals.
Chan DC. (2006)
17 more

5 mentions without citation

Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm.
Wells et al. (2007)
4 more