› 1yae

X-ray diffraction
3.11Å resolution

Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid

Released:
DOI: 10.2210/pdb1yae/pdb
PDB entry 1yae coloured by chain, front view.
PDB entry 1yae coloured by chain, side view.
PDB entry 1yae coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid.
Nanao MH, Green T, Stern-Bach Y, Heinemann SF, Choe S
Proc Natl Acad Sci U S A 102 1708-13 (2005)
PMID: 15677325

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glutamate receptor ionotropic, kainate 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 312 amino acids
Theoretical weight: 35.12 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P42260 (Residues: 419-557, 662-819; Coverage: 34%)
Gene names: Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand DOQ 6 x DOQ
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 246.36Å b: 106.57Å c: 172.69Å
α: 90° β: 133.19° γ: 90°
R-values:
R R work R free
0.278 0.275 0.334
Expression system: Trichoplusia ni

Quick links

Citations

18 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
17 more

5 mentions without citation

Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid.
Nanao et al. (2005)
4 more