Function and Biology Details
Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase T1A, proteasome beta-subunit
- Nucleophile aminohydrolases, N-terminal
- Peptidase T1A, proteasome beta-subunit, archaeal
- Proteasome alpha subunit, archaeal
- Proteasome B-type subunit
- Proteasome, subunit alpha/beta
- Proteasome activator PA28, C-terminal domain
- Proteasome activator superfamily
4 more domains
Structure domains:
Structure analysis Details
Assembly composition:
hetero 42-mer (preferred)
Assembly name:
Proteasome complex (preferred)
PDBe Complex ID:
PDB-CPX-150393 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proteasome subunit alpha
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 233 amino acids
Theoretical weight: 25.8 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Length: 233 amino acids
Theoretical weight: 25.8 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P25156 (Residues: 1-233; Coverage: 100%)
Sequence domains:
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome subunit beta
Molecule details ›
Chains: H, I, J, K, L, M, N
Length: 217 amino acids
Theoretical weight: 24 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Proteasome subunit
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Length: 217 amino acids
Theoretical weight: 24 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P28061 (Residues: 1-211; Coverage: 100%)
Sequence domains: Proteasome subunit
Structure domains: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Proteasome activator PA28 C-terminal domain-containing protein
Molecule details ›
Chains: O, P, Q, R, S, T, U
Length: 237 amino acids
Theoretical weight: 26.09 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli BL21(DE3)
UniProt:
Structure domains: Proteasome activator pa28, C-terminal domain
Length: 237 amino acids
Theoretical weight: 26.09 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9U8G2 (Residues: 2-231; Coverage: 100%)
Structure domains: Proteasome activator pa28, C-terminal domain
