› 1yc9

X-ray diffraction
1.8Å resolution

The crystal structure of the outer membrane protein VceC from the bacterial pathogen Vibrio cholerae at 1.8 resolution

Released:
DOI: 10.2210/pdb1yc9/pdb
PDB entry 1yc9 coloured by chain, front view.
PDB entry 1yc9 coloured by chain, side view.
PDB entry 1yc9 coloured by chain, top view.
Source organism: Vibrio cholerae
Primary publication:
The crystal structure of the outer membrane protein VceC from the bacterial pathogen Vibrio cholerae at 1.8 A resolution.
Federici L, Du D, Walas F, Matsumura H, Fernandez-Recio J, McKeegan KS, Borges-Walmsley MI, Luisi BF, Walmsley AR
J Biol Chem 280 15307-14 (2005)
PMID: 15684414

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192067 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug resistance protein, putative Chain: A
Molecule details ›
Chain: A
Length: 442 amino acids
Theoretical weight: 47.68 KDa
Source organism: Vibrio cholerae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9KS51 (Residues: 43-484; Coverage: 91%)
Gene name: VC_1409
Sequence domains: Outer membrane efflux protein
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand BOG 1 x BOG
Ligand HG 2 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P321
Unit cell:
a: 71.458Å b: 71.458Å c: 190.702Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.189 0.221
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Efflux-mediated drug resistance in bacteria: an update.
Li et al. (2009)
17 more

13 mentions without citation

The structural biology of β-barrel membrane proteins: a summary of recent reports.
Fairman et al. (2011)
12 more