› 1yd9

X-ray diffraction
1.6Å resolution

1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.

Released:
DOI: 10.2210/pdb1yd9/pdb
PDB entry 1yd9 coloured by chain, front view.
PDB entry 1yd9 coloured by chain, side view.
PDB entry 1yd9 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural characterization of the histone variant macroH2A.
Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K
Mol Cell Biol 25 7616-24 (2005)
PMID: 16107708

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169778 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Core histone macro-H2A.1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 193 amino acids
Theoretical weight: 20.54 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02874 (Residues: 176-368; Coverage: 52%)
Gene names: H2afy, Macroh2a1
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

1 bound ligand:
Ligand AU 4 x AU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 83.114Å b: 89.791Å c: 95.679Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.235 0.26
Expression system: Escherichia coli

Quick links

Citations

39 review citations

Nucleosome structure and function.
McGinty et al. (2015)
38 more

9 mentions without citation

The Role of MacroH2A Histone Variants in Cancer.
Hsu et al. (2021)
8 more