› 1yed

X-ray diffraction
3.1Å resolution

STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4)

Released:
DOI: 10.2210/pdb1yed/pdb
PDB entry 1yed coloured by chain, front view.
PDB entry 1yed coloured by chain, side view.
PDB entry 1yed coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural convergence in the active sites of a family of catalytic antibodies.
Charbonnier JB, Golinelli-Pimpaneau B, Gigant B, Tawfik DS, Chap R, Schindler DG, Kim SH, Green BS, Eshhar Z, Knossow M
Science 275 1140-2 (1997)
PMID: 9027317

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224995 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IGG1 FAB FRAGMENT (D.2.4) Chains: A, L
Molecule details ›
Chains: A, L
Length: 219 amino acids
Theoretical weight: 24.09 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Ig gamma-1 chain C region secreted form Chains: B, H
Molecule details ›
Chains: B, H
Length: 226 amino acids
Theoretical weight: 24.5 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01868 (Residues: 1-102; Coverage: 32%)
Gene names: Igh-4, Ighg1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand PNB 2 x PNB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE D41A
Spacegroup: C2221
Unit cell:
a: 99.25Å b: 104.79Å c: 223.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.26

Quick links

Citations

8 review citations

Critical analysis of antibody catalysis.
Hilvert D. (2000)
7 more