› 1ygj

X-ray diffraction
2.7Å resolution

Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives

Released:
DOI: 10.2210/pdb1ygj/pdb
PDB entry 1ygj coloured by chain, front view.
PDB entry 1ygj coloured by chain, side view.
PDB entry 1ygj coloured by chain, top view.
Source organism: Ovis aries
Primary publication:
Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.
Tang L, Li MH, Cao P, Wang F, Chang WR, Bach S, Reinhardt J, Ferandin Y, Galons H, Wan Y, Gray N, Meijer L, Jiang T, Liang DC
J Biol Chem 280 31220-9 (2005)
PMID: 15985434

Function and Biology Details

Reaction catalysed: 
ATP + pyridoxal = ADP + pyridoxal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160608 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyridoxal kinase Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 34.86 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P82197 (Residues: 1-312; Coverage: 100%)
Gene names: PDXK, PKH
Sequence domains: Phosphomethylpyrimidine kinase
Structure domains: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase

Ligands and Environments

1 bound ligand:
Ligand RMC 1 x RMC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 100.864Å b: 100.864Å c: 55.706Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.217 0.28

Quick links

Citations

7 review citations

Roscovitine in cancer and other diseases.
Cicenas et al. (2015)
6 more

1 mention without citation

The surface lipoproteins of gram-negative bacteria: Protectors and foragers in harsh environments.
Cole et al. (2021)