› 1yi5

X-ray diffraction
4.2Å resolution

Crystal structure of the a-cobratoxin-AChBP complex

Released:
DOI: 10.2210/pdb1yi5/pdb
PDB entry 1yi5 coloured by chain, front view.
PDB entry 1yi5 coloured by chain, side view.
PDB entry 1yi5 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors.
Bourne Y, Talley TT, Hansen SB, Taylor P, Marchot P
EMBO J 24 1512-22 (2005)
PMID: 15791209

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134302 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acetylcholine-binding protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 210 amino acids
Theoretical weight: 23.86 KDa
Source organism: Lymnaea stagnalis
UniProt:
  • Canonical: P58154 (Residues: 20-229; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Alpha-cobratoxin Chains: F, G, H, I, J
Molecule details ›
Chains: F, G, H, I, J
Length: 71 amino acids
Theoretical weight: 7.84 KDa
Source organism: Naja siamensis
UniProt:
  • Canonical: P01391 (Residues: 1-71; Coverage: 100%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2221
Unit cell:
a: 162.604Å b: 313.415Å c: 106.548Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.333 0.331 0.378

Quick links

Citations

41 review citations

Mammalian nicotinic acetylcholine receptors: from structure to function.
Albuquerque et al. (2009)
40 more

36 mentions without citation

Molecular dynamics simulations and drug discovery.
Durrant et al. (2011)
35 more