› 1yiy

X-ray diffraction
1.9Å resolution

Aedes aegypti kynurenine aminotransferase

Released:
DOI: 10.2210/pdb1yiy/pdb
PDB entry 1yiy coloured by chain, front view.
PDB entry 1yiy coloured by chain, side view.
PDB entry 1yiy coloured by chain, top view.
Source organism: Aedes aegypti
Primary publication:
Crystal structures of Aedes aegypti kynurenine aminotransferase.
Han Q, Gao YG, Robinson H, Ding H, Wilson S, Li J
FEBS J 272 2198-206 (2005)
PMID: 15853804

Function and Biology Details

Reactions catalysed: 
(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine 
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kynurenine aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 429 amino acids
Theoretical weight: 48.34 KDa
Source organism: Aedes aegypti
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q17CS8 (Residues: 49-477; Coverage: 90%)
Gene names: AAEL004435, KAT
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments


Cofactor: Ligand PMP 2 x PMP
1 bound ligand:
Ligand BR 5 x BR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P212121
Unit cell:
a: 55.358Å b: 95.316Å c: 167.674Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 not available
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.
Han et al. (2010)
2 more

6 mentions without citation

Structural perspective on mutations affecting the function of multisubunit RNA polymerases.
Trinh et al. (2006)
5 more