› 1yje

X-ray diffraction
2.4Å resolution

Crystal structure of the rNGFI-B ligand-binding domain

Released:
DOI: 10.2210/pdb1yje/pdb
PDB entry 1yje coloured by chain, front view.
PDB entry 1yje coloured by chain, side view.
PDB entry 1yje coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain.
Flaig R, Greschik H, Peluso-Iltis C, Moras D
J Biol Chem 280 19250-8 (2005)
PMID: 15716272

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149807 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 4 group A member 1 Chain: A
Molecule details ›
Chain: A
Length: 264 amino acids
Theoretical weight: 29.27 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P22829 (Residues: 354-597; Coverage: 41%)
Gene names: Hmr, Ngfib, Nr4a1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: I4122
Unit cell:
a: 90.422Å b: 90.422Å c: 140.637Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.243 0.278
Expression system: Escherichia coli BL21

Quick links

Citations

22 review citations

Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.
Pearen et al. (2010)
21 more

5 mentions without citation

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes.
Zhang et al. (2020)
4 more