› 1yjo

X-ray diffraction
1.3Å resolution

Structure of NNQQNY from yeast prion Sup35 with zinc acetate

Released:
DOI: 10.2210/pdb1yjo/pdb
PDB entry 1yjo coloured by chain, front view.
PDB entry 1yjo coloured by chain, side view.
PDB entry 1yjo coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Structure of the cross-beta spine of amyloid-like fibrils.
Nelson R, Sawaya MR, Balbirnie M, Madsen AØ, Riekel C, Grothe R, Eisenberg D
Nature 435 773-8 (2005)
PMID: 15944695

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138677 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic peptide chain release factor GTP-binding subunit Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 780 Da
Source organism: Saccharomyces cerevisiae S288C
Expression system: Not provided
UniProt:
  • Canonical: P05453 (Residues: 8-13; Coverage: 1%)
Gene names: GST1, PNM2, SAL3, SUF12, SUP2, SUP35, YD9395.05, YDR172W

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand ACY 1 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21
Unit cell:
a: 21.153Å b: 4.87Å c: 23.13Å
α: 90° β: 102.93° γ: 90°
R-values:
R R work R free
0.103 0.102 0.152
Expression system: Not provided

Quick links

Citations

310 review citations

Protein misfolding, functional amyloid, and human disease.
Chiti et al. (2006)
309 more

16 mentions without citation

Structure of the cross-beta spine of amyloid-like fibrils.
Nelson et al. (2005)
15 more