› 1ymg

X-ray diffraction
2.24Å resolution

The Channel Architecture of Aquaporin O at 2.2 Angstrom Resolution

Released:
DOI: 10.2210/pdb1ymg/pdb
PDB entry 1ymg coloured by chain, front view.
PDB entry 1ymg coloured by chain, side view.
PDB entry 1ymg coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The channel architecture of aquaporin 0 at a 2.2-A resolution.
Harries WE, Akhavan D, Miercke LJ, Khademi S, Stroud RM
Proc Natl Acad Sci U S A 101 14045-50 (2004)
PMID: 15377788

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139107 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lens fiber major intrinsic protein Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 28.24 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P06624 (Residues: 1-263; Coverage: 100%)
Gene name: MIP
Sequence domains: Major intrinsic protein
Structure domains: Glycerol uptake facilitator protein.

Ligands and Environments

1 bound ligand:
Ligand BNG 2 x BNG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P4212
Unit cell:
a: 110.531Å b: 110.531Å c: 53.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.24 0.303

Quick links

Citations

39 review citations

Human aquaporins: regulators of transcellular water flow.
Day et al. (2014)
38 more

26 mentions without citation

Aquaporins: important but elusive drug targets.
Verkman et al. (2014)
25 more