› 1yua

Solution NMR

C-TERMINAL DOMAIN OF ESCHERICHIA COLI TOPOISOMERASE I

Released:
DOI: 10.2210/pdb1yua/pdb
PDB entry 1yua coloured by chain, ensemble of 26 models, front view.
PDB entry 1yua coloured by chain, ensemble of 26 models, side view.
PDB entry 1yua coloured by chain, ensemble of 26 models, top view.
Source organism: Escherichia coli
Primary publication:
Solution structure of the C-terminal single-stranded DNA-binding domain of Escherichia coli topoisomerase I.
Yu L, Zhu CX, Tse-Dinh YC, Fesik SW
Biochemistry 34 7622-8 (1995)
PMID: 7779808

Function and Biology Details

Reaction catalysed: 
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139094 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA topoisomerase 1 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.86 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P06612 (Residues: 745-865; Coverage: 14%)
Gene names: JW1266, b1274, supX, topA
Sequence domains: Topoisomerase I zinc-ribbon-like
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

11 review citations

DNA topoisomerases: structure, function, and mechanism.
Champoux JJ. (2001)
10 more

7 mentions without citation

Chemical shift prediction for protein structure calculation and quality assessment using an optimally parameterized force field.
Nielsen et al. (2012)
6 more