› 1yxa

X-ray diffraction
2.1Å resolution

Serpina3n, a murine orthologue of human antichymotrypsin

Released:
DOI: 10.2210/pdb1yxa/pdb
PDB entry 1yxa coloured by chain, front view.
PDB entry 1yxa coloured by chain, side view.
PDB entry 1yxa coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins.
Horvath AJ, Irving JA, Rossjohn J, Law RH, Bottomley SP, Quinsey NS, Pike RN, Coughlin PB, Whisstock JC
J Biol Chem 280 43168-78 (2005)
PMID: 16141197

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187580 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor A3N Chains: A, B
Molecule details ›
Chains: A, B
Length: 398 amino acids
Theoretical weight: 44.79 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q91WP6 (Residues: 21-418; Coverage: 100%)
Gene names: Serpina3n, Spi2
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 83.34Å b: 92.62Å c: 118.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.239
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Inflammation-related genes up-regulated in schizophrenia brains.
Saetre et al. (2007)
9 more