› 1yxh

X-ray diffraction
1.86Å resolution

Crystal structure of a novel phospholipase A2 from Naja naja sagittifera with a strong anticoagulant activity

Released:
DOI: 10.2210/pdb1yxh/pdb
PDB entry 1yxh coloured by chain, front view.
PDB entry 1yxh coloured by chain, side view.
PDB entry 1yxh coloured by chain, top view.
Source organism: Naja sagittifera
Primary publication:
Crystal structure of a novel phospholipase A2 from Naja naja sagittifera with a strong anticoagulant activity.
Jabeen T, Singh N, Singh RK, Ethayathulla AS, Sharma S, Srinivasan A, Singh TP
Toxicon 46 865-75 (2005)
PMID: 16269164

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180348 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 4 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.21 KDa
Source organism: Naja sagittifera
UniProt:
  • Canonical: Q6T179 (Residues: 1-126; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand PO4 1 x PO4
Ligand EOH 2 x EOH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41
Unit cell:
a: 42.817Å b: 42.817Å c: 65.994Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.195 0.225

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Citations

3 review citations

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.
Kang et al. (2011)
2 more

3 mentions without citation

Expression, functional, and structural analysis of proteins critical for otoconia development.
Xu et al. (2010)
2 more