› 1z8f

X-ray diffraction
2.5Å resolution

Guanylate Kinase Double Mutant A58C, T157C from Mycobacterium tuberculosis (Rv1389)

Released:
DOI: 10.2210/pdb1z8f/pdb
PDB entry 1z8f coloured by chain, front view.
PDB entry 1z8f coloured by chain, side view.
PDB entry 1z8f coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Entry authors: Chan S, Sawaya MR, Choi B, Zocchi G, Perry LJ, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)

Function and Biology Details

Reaction catalysed: 
ATP + GMP = ADP + GDP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161738 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate kinase Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 24.32 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WKE9 (Residues: 2-208; Coverage: 100%)
Gene names: MTCY21B4.06, Rv1389, gmk
Sequence domains: Guanylate kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FMT 2 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: I23
Unit cell:
a: 112.306Å b: 112.306Å c: 112.306Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.236
Expression system: Escherichia coli

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