› 1za8

Solution NMR

NMR solution structure of a leaf-specific-expressed cyclotide vhl-1

Released:
DOI: 10.2210/pdb1za8/pdb
PDB entry 1za8 coloured by chain, ensemble of 20 models, front view.
PDB entry 1za8 coloured by chain, ensemble of 20 models, side view.
PDB entry 1za8 coloured by chain, ensemble of 20 models, top view.
Source organism: Viola hederacea
Primary publication:
Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.
Chen B, Colgrave ML, Daly NL, Rosengren KJ, Gustafson KR, Craik DJ
J Biol Chem 280 22395-405 (2005)
PMID: 15824119

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160890 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leaf cyclotide 1 Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.34 KDa
Source organism: Viola hederacea
UniProt:
  • Canonical: P84522 (Residues: 4-31; Coverage: 90%)
Sequence domains: Cyclotide family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics

Quick links

Citations

23 review citations

The cyclotide family of circular miniproteins: nature's combinatorial peptide template.
Craik et al. (2006)
22 more

3 mentions without citation

Host-defense activities of cyclotides.
Craik DJ. (2012)
2 more