› 1zc0

X-ray diffraction
1.85Å resolution

Crystal structure of human hematopoietic tyrosine phosphatase (HePTP) catalytic domain

Released:
DOI: 10.2210/pdb1zc0/pdb
PDB entry 1zc0 coloured by chain, front view.
PDB entry 1zc0 coloured by chain, side view.
PDB entry 1zc0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site.
Mustelin T, Tautz L, Page R
J Mol Biol 354 150-63 (2005)
PMID: 16226275

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152862 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 7 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35236 (Residues: 65-360; Coverage: 82%)
Gene name: PTPN7
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P61
Unit cell:
a: 127.101Å b: 127.101Å c: 59.863Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.163 0.161 0.186
Expression system: Escherichia coli

Quick links

Citations

10 review citations

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships.
Zeke et al. (2016)
9 more

3 mentions without citation

Generation of inhibitor-sensitive protein tyrosine phosphatases via active-site mutations.
Bishop et al. (2007)
2 more