› 1zcd

X-ray diffraction
3.45Å resolution

Crystal structure of the Na+/H+ antiporter NhaA

Released:
DOI: 10.2210/pdb1zcd/pdb
PDB entry 1zcd coloured by chain, front view.
PDB entry 1zcd coloured by chain, side view.
PDB entry 1zcd coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH.
Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H
Nature 435 1197-202 (2005)
PMID: 15988517

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146738 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) antiporter NhaA Chains: A, B
Molecule details ›
Chains: A, B
Length: 388 amino acids
Theoretical weight: 41.39 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P13738 (Residues: 1-388; Coverage: 100%)
Gene names: JW0018, ant, b0019, nhaA
Sequence domains: Na+/H+ antiporter 1
Structure domains: Na+/H+ antiporter like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29, ESRF BEAMLINE ID23-1, SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 108.868Å b: 121.718Å c: 123.578Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.302 0.316 0.316
Expression system: Escherichia coli

Quick links

Citations

83 review citations

Physiology of cell volume regulation in vertebrates.
Hoffmann et al. (2009)
82 more

44 mentions without citation

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes.
Lundbaek et al. (2010)
43 more