› 1zdl

X-ray diffraction
3Å resolution

Crystal Structure of Mouse Thioredoxin Reductase Type 2

Released:
DOI: 10.2210/pdb1zdl/pdb
PDB entry 1zdl coloured by chain, front view.
PDB entry 1zdl coloured by chain, side view.
PDB entry 1zdl coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.
Biterova EI, Turanov AA, Gladyshev VN, Barycki JJ
Proc Natl Acad Sci U S A 102 15018-23 (2005)
PMID: 16217027

Function and Biology Details

Reaction catalysed: 
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin reductase 2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 517 amino acids
Theoretical weight: 55.82 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JLT4 (Residues: 31-524; Coverage: 94%)
Gene names: Trxr2, Txnrd2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NDP 1 x NDP

Cofactor: Ligand FAD 1 x FAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: I4122
Unit cell:
a: 109.07Å b: 109.07Å c: 204.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.241 0.31
Expression system: Escherichia coli

Quick links

Citations

16 review citations

From selenium to selenoproteins: synthesis, identity, and their role in human health.
Papp et al. (2007)
15 more

3 mentions without citation

Selenoproteins: molecular pathways and physiological roles.
Labunskyy et al. (2014)
2 more