› 1zlc

Solution NMR

Solution Conformation of alpha-conotoxin PIA

Released:
DOI: 10.2210/pdb1zlc/pdb
PDB entry 1zlc coloured by chain, ensemble of 20 models, front view.
PDB entry 1zlc coloured by chain, ensemble of 20 models, side view.
PDB entry 1zlc coloured by chain, ensemble of 20 models, top view.
Source organism: Conus purpurascens
Primary publication:
Solution structure of alpha-conotoxin PIA, a novel antagonist of alpha6 subunit containing nicotinic acetylcholine receptors.
Chi SW, Lee SH, Kim DH, Kim JS, Olivera BM, McIntosh JM, Han KH
Biochem Biophys Res Commun 338 1990-7 (2005)
PMID: 16289101

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin PIA Chain: A
Molecule details ›
Chain: A
Length: 19 amino acids
Theoretical weight: 1.99 KDa
Source organism: Conus purpurascens
Expression system: Not provided
UniProt:
  • Canonical: P69658 (Residues: 22-39; Coverage: 45%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.
Azam et al. (2009)
1 more

4 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
3 more