› 1zp2

X-ray diffraction
3Å resolution

Structure of the Mediator subunit cyclin C

Released:
DOI: 10.2210/pdb1zp2/pdb
PDB entry 1zp2 coloured by chain, front view.
PDB entry 1zp2 coloured by chain, side view.
PDB entry 1zp2 coloured by chain, top view.
Source organism: Schizosaccharomyces pombe
Primary publication:
Structure of the mediator subunit cyclin C and its implications for CDK8 function.
Hoeppner S, Baumli S, Cramer P
J Mol Biol 350 833-42 (2005)
PMID: 15979093

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-131714 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA polymerase II holoenzyme cyclin-like subunit Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 27.1 KDa
Source organism: Schizosaccharomyces pombe
Expression system: Escherichia coli
UniProt:
  • Canonical: O94503 (Residues: 5-228; Coverage: 98%)
Gene names: SPBC12D12.06, srb11
Sequence domains: Cyclin, N-terminal domain
Structure domains: Cyclin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3121
Unit cell:
a: 91.7Å b: 91.7Å c: 91.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.29 0.244 0.288
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators.
Hahn et al. (2011)
10 more

2 mentions without citation

Cyclin box structure of the P-TEFb subunit cyclin T1 derived from a fusion complex with EIAV tat.
Anand et al. (2007)
1 more