1zps

X-ray diffraction
1.7Å resolution

Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI

Released:

Function and Biology Details

Reaction catalysed:
1-(5-phospho-beta-D-ribosyl)-AMP + H(2)O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-127835 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoribosyl-AMP cyclohydrolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 15.48 KDa
Source organism: Methanothermobacter thermautotrophicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O26347 (Residues: 1-138; Coverage: 100%)
Gene names: MTH_245, hisI
Sequence domains: Phosphoribosyl-AMP cyclohydrolase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P212121
Unit cell:
a: 39.783Å b: 54.358Å c: 117.362Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.235
Expression system: Escherichia coli