› 1ztg

X-ray diffraction
3Å resolution

human alpha polyC binding protein KH1

Released:
DOI: 10.2210/pdb1ztg/pdb
PDB entry 1ztg coloured by chain, front view.
PDB entry 1ztg coloured by chain, side view.
PDB entry 1ztg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides.
Yoga YM, Traore DA, Sidiqi M, Szeto C, Pendini NR, Barker A, Leedman PJ, Wilce JA, Wilce MC
Nucleic Acids Res 40 5101-14 (2012)
PMID: 22344691

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114959 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Poly(rC)-binding protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 74 amino acids
Theoretical weight: 8.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15365 (Residues: 14-85; Coverage: 20%)
Gene name: PCBP1
Sequence domains: KH domain
Structure domains: K Homology domain, type 1
5'-D(P*CP*CP*CP*TP*CP*CP*CP*T)-3' Chains: Y, Z
Molecule details ›
Chains: Y, Z
Length: 8 nucleotides
Theoretical weight: 2.3 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 45.6Å b: 76.8Å c: 61.4Å
α: 90° β: 111.7° γ: 90°
R-values:
R R work R free
0.243 0.24 0.293
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

Single-stranded DNA-binding proteins: multiple domains for multiple functions.
Dickey et al. (2013)
3 more

7 mentions without citation

Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles.
Chaudhury et al. (2010)
6 more