› 1zv7

X-ray diffraction
1.7Å resolution

A structure-based mechanism of SARS virus membrane fusion

Released:
DOI: 10.2210/pdb1zv7/pdb
PDB entry 1zv7 coloured by chain, front view.
PDB entry 1zv7 coloured by chain, side view.
PDB entry 1zv7 coloured by chain, top view.
Source organism: SARS coronavirus FRA
Primary publication:
Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein.
Deng Y, Liu J, Zheng Q, Yong W, Lu M
Structure 14 889-99 (2006)
PMID: 16698550

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157819 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spike protein S2' Chains: A, B
Molecule details ›
Chains: A, B
Length: 44 amino acids
Theoretical weight: 5.02 KDa
Source organism: SARS coronavirus FRA
Expression system: Escherichia coli
UniProt:
  • Canonical: P59594 (Residues: 1150-1193; Coverage: 4%)
Gene names: 2, S

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C222
Unit cell:
a: 43.65Å b: 90.213Å c: 42.256Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.258
Expression system: Escherichia coli

Quick links

Citations

11 review citations

COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives.
Sun et al. (2020)
10 more

5 mentions without citation

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.
Hilgenfeld et al. (2013)
4 more