› 1zxk

X-ray diffraction
2Å resolution

Crystal Structure of Cadherin8 EC1 domain

Released:
DOI: 10.2210/pdb1zxk/pdb
PDB entry 1zxk coloured by chain, front view.
PDB entry 1zxk coloured by chain, side view.
PDB entry 1zxk coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Type II cadherin ectodomain structures: implications for classical cadherin specificity.
Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L
Cell 124 1255-68 (2006)
PMID: 16564015

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161284 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 98 amino acids
Theoretical weight: 11.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P97291 (Residues: 62-159; Coverage: 13%)
Gene name: Cdh8
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P2
Unit cell:
a: 46.196Å b: 39.934Å c: 66.439Å
α: 90° β: 110.68° γ: 90°
R-values:
R R work R free
0.254 0.252 0.283
Expression system: Escherichia coli

Quick links

Citations

56 review citations

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
Hartsock et al. (2008)
55 more

5 mentions without citation

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins.
Vendome et al. (2011)
4 more