› 1zzj

X-ray diffraction
2.3Å resolution

Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA

Released:
DOI: 10.2210/pdb1zzj/pdb
PDB entry 1zzj coloured by chain, front view.
PDB entry 1zzj coloured by chain, side view.
PDB entry 1zzj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids.
Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S
Structure 13 1055-67 (2005)
PMID: 16004877

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114969 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoprotein K Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 82 amino acids
Theoretical weight: 8.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61978 (Residues: 385-463; Coverage: 17%)
Gene names: HNRNPK, HNRPK
Sequence domains: KH domain
Structure domains: K Homology domain, type 1
5'-D(*TP*TP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*TP*TP*T)-3' Chain: D
Molecule details ›
Chain: D
Length: 15 nucleotides
Theoretical weight: 4.41 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 54.008Å b: 54.008Å c: 149.656Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.21 0.283
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

17 review citations

RNA-binding proteins: modular design for efficient function.
Lunde et al. (2007)
16 more

3 mentions without citation

The Repurposing of Cellular Proteins during Enterovirus A71 Infection.
Abedeera et al. (2023)
2 more