› 207d

Solution NMR

SOLUTION STRUCTURE OF MITHRAMYCIN DIMERS BOUND TO PARTIALLY OVERLAPPING SITES ON DNA

Released:
DOI: 10.2210/pdb207d/pdb
PDB entry 207d coloured by chain, ensemble of 8 models, front view.
PDB entry 207d coloured by chain, ensemble of 8 models, side view.
PDB entry 207d coloured by chain, ensemble of 8 models, top view.
Source organism: synthetic construct
Primary publication:
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA.
Sastry M, Fiala R, Patel DJ
J Mol Biol 251 674-89 (1995)
PMID: 7666419

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114976 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecules (3 distinct):
DNA (5'-D(*TP*AP*GP*CP*TP*AP*GP*CP*TP*A)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 10 nucleotides
Theoretical weight: 3.04 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: DDA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: DDA, DDL, MDA
Carbohydrate polymer
2 bound ligands:
Ligand MG 2 x MG
Ligand CRH 4 x CRH
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

6 review citations

The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.
Lombó et al. (2006)
5 more

1 mention without citation

PDBSiteScan: a program for searching for active, binding and posttranslational modification sites in the 3D structures of proteins.
Ivanisenko et al. (2004)