› 236d

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF FOUR MORPHOLINO-DOXORUBICIN ANTICANCER DRUGS COMPLEXED WITH D(CGTACG) AND D(CGATCG): IMPLICATIONS IN DRUG-DNA CROSSLINK

Released:
DOI: 10.2210/pdb236d/pdb
PDB entry 236d coloured by chain, front view.
PDB entry 236d coloured by chain, side view.
PDB entry 236d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal structures of four morpholino-doxorubicin anticancer drugs complexed with d(CGTACG) and d(CGATCG): implications in drug-DNA crosslink.
Gao YG, Wang AH
J Biomol Struct Dyn 13 103-17 (1995)
PMID: 8527023

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115001 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*AP*TP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CMD 1 x CMD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 28.186Å b: 28.186Å c: 53.352Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 not available not available
Expression system: Not provided

Quick links

Citations

7 citation in other articles

CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity.
Colombo et al. (2009)
6 more

2 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
1 more