› 244d

X-ray diffraction
1.2Å resolution

THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX

Released:
DOI: 10.2210/pdb244d/pdb
PDB entry 244d coloured by chain, front view.
PDB entry 244d coloured by chain, side view.
PDB entry 244d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
The high-resolution crystal structure of a parallel-stranded guanine tetraplex.
Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B
Science 265 520-4 (1994)
PMID: 8036494

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115009 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*GP*GP*GP*GP*T)-3') Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NA 14 x NA
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 28.76Å b: 35.47Å c: 56.77Å
α: 74.39° β: 77.64° γ: 89.73°
R-values:
R R work R free
0.124 not available 0.176
Expression system: Not provided

Quick links

Citations

35 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
34 more

13 mentions without citation

G-Quadruplexes as An Alternative Recognition Element in Disease-Related Target Sensing.
Ida et al. (2019)
12 more