› 276d

X-ray diffraction
1.8Å resolution

SUBSTITUTIONS AT C2' OF DAUNOSAMINE IN THE ANTICANCER DAUNORUBICIN ALTER ITS DNA-BINDING SEQUENCE SPECIFICITY

Released:
DOI: 10.2210/pdb276d/pdb
PDB entry 276d coloured by chain, front view.
PDB entry 276d coloured by chain, side view.
PDB entry 276d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Substitutions at C2' of daunosamine in the anticancer drug daunorubicin alter its DNA-binding sequence specificity.
Gao YG, Priebe W, Wang AH
Eur J Biochem 240 331-5 (1996)
PMID: 8841395

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115034 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*AP*TP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM8 1 x DM8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P41212
Unit cell:
a: 28.09Å b: 28.09Å c: 53.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 not available not available
Expression system: Not provided

Quick links

Citations

1 review citation

How can we use our growing understanding of gene transcription to discover effective new medicines?
Latchman DS. (1997)
5 other articles

2 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
1 more