› 2a07

X-ray diffraction
1.9Å resolution

Crystal Structure of Foxp2 bound Specifically to DNA.

Released:
DOI: 10.2210/pdb2a07/pdb
PDB entry 2a07 coloured by chain, front view.
PDB entry 2a07 coloured by chain, side view.
PDB entry 2a07 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the forkhead domain of FOXP2 bound to DNA.
Stroud JC, Wu Y, Bates DL, Han A, Nowick K, Paabo S, Tong H, Chen L
Structure 14 159-66 (2006)
PMID: 16407075

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115056 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Forkhead box protein P2 Chains: F, G, H, I, J, K
Molecule details ›
Chains: F, G, H, I, J, K
Length: 93 amino acids
Theoretical weight: 11.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15409 (Residues: 502-594; Coverage: 13%)
Gene names: CAGH44, FOXP2, TNRC10
Sequence domains: Forkhead domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3' Chains: A, C
Molecule details ›
Chains: A, C
Length: 21 nucleotides
Theoretical weight: 6.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3' Chains: B, D
Molecule details ›
Chains: B, D
Length: 21 nucleotides
Theoretical weight: 6.49 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MG 6 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P21
Unit cell:
a: 67.542Å b: 124.21Å c: 67.666Å
α: 90° β: 110.81° γ: 90°
R-values:
R R work R free
0.231 0.222 0.244
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

23 review citations

A census of human transcription factors: function, expression and evolution.
Vaquerizas et al. (2009)
22 more

19 mentions without citation

Protein acrobatics in pairs--dimerization via domain swapping.
Gronenborn AM. (2009)
18 more