› 2a0m

X-ray diffraction
1.6Å resolution

Function and Biology Details

Reaction catalysed: 
N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-175484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase, putative Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 34.68 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4DSA0 (Residues: 1-308; Coverage: 100%)
Gene name: Tc00.1047053507031.90
Sequence domains: Arginase family
Structure domains: Ureohydrolase domain

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: R3
Unit cell:
a: 128.875Å b: 128.875Å c: 42.671Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.168 0.168 0.195
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Global phenotypic screening for antimalarials.
Guiguemde et al. (2012)
6 more

1 mention without citation

Formiminoglutamase from Trypanosoma cruzi is an arginase-like manganese metalloenzyme.
Hai et al. (2013)