› 2a3w

X-ray diffraction
2.2Å resolution

Decameric structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane

Released:
DOI: 10.2210/pdb2a3w/pdb
PDB entry 2a3w coloured by chain, front view.
PDB entry 2a3w coloured by chain, side view.
PDB entry 2a3w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands.
Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK
J Biol Chem 280 31999-2008 (2005)
PMID: 16036920

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136122 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid P-component Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Length: 204 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02743 (Residues: 20-223; Coverage: 100%)
Gene names: APCS, PTX2
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 40 x CA
Ligand CPJ 10 x CPJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P1
Unit cell:
a: 96.712Å b: 105.325Å c: 146.007Å
α: 86.53° β: 78.15° γ: 76.78°
R-values:
R R work R free
0.19 0.188 0.229

Quick links

Citations

2 review citations

Bacterial toxin inhibitors based on multivalent scaffolds.
Branson et al. (2013)
1 more

1 mention without citation

Computational Insights into Compaction of Gas-Phase Protein and Protein Complex Ions in Native Ion Mobility-Mass Spectrometry.
Rolland et al. (2019)