› 2a3x

X-ray diffraction
3Å resolution

Decameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy- 2-methyl-1,3-dioxane]- 5-yloxycarbonyl}-piperazine

Released:
DOI: 10.2210/pdb2a3x/pdb
PDB entry 2a3x coloured by chain, front view.
PDB entry 2a3x coloured by chain, side view.
PDB entry 2a3x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands.
Ho JG, Kitov PI, Paszkiewicz E, Sadowska J, Bundle DR, Ng KK
J Biol Chem 280 31999-2008 (2005)
PMID: 16036920

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136122 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid P-component Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 204 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02743 (Residues: 20-223; Coverage: 100%)
Gene names: APCS, PTX2
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 20 x CA
Ligand CPK 3 x CPK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 77.861Å b: 95.054Å c: 164.257Å
α: 90° β: 98.74° γ: 90°
R-values:
R R work R free
0.231 0.228 0.282

Quick links

Citations

2 review citations

Bacterial toxin inhibitors based on multivalent scaffolds.
Branson et al. (2013)
1 more

2 mentions without citation

The yin-yang of long pentraxin PTX3 in inflammation and immunity.
Daigo et al. (2014)
1 more